Digital Image Processing Lab
Department of Radiology, University of Michigan
An Application of MI-based Automated Registration:
Functional Magnetic Resonance Images of the Human Brain
Boklye Kim, Thomas Chenevert, John Jonides*, Charles Meyer
Digital Image Processing Laboratory
Department of Radiology, University of Michigan Medical Center
*Department of Psychology, University of Michigan
Functional MR images were acquired using an EPI (Echo Planar
Imaging) system available on the GE Signa 1.5 Tesla scanner in the
Radiology Department of the University of Michigan Medical Center.
Time-series gradient echo planar images of functional response to
each activation paradigm (motor or visual stimulation) were acquired.
Signal processing was performed using a paired t-statistics test to
determine functional significance of voxel intensity changes due to the
activation of each paradigm.
The resulting functional volume was then mapped onto the anatomical
reference image of the same subject acquired in the same session using
3D SPGR.
The registered volumes are superimposed to create a brain activation
image with functional and anatomic information.
The functional images were colorized in red and blue to represent
temporal positive and negative correlations, respectively, in the unilateral
activation cycle.
Volume rendering was performed to create 3D model of functional-anatomic image data.
Motor Stimulation: Finger Tapping Paradigm (Figure 1)
- Unilateral motor function: alternating hand, finger tapping motions
- Functional images: Axial EPI; FOV= 240 mm2; slice thickness = 8 mm;64x64x5
- Anatomical volume: Axial SPGR; FOV = 200 mm2; slice thickness = 2mm; 256x256x40
Figure 1. (13K color, 312x505 gif)
Visual Field Stimulation Paradigm (Figure 2)
- Functional images: Coronal EPI; FOV=240 mm2; slice thickness=6mm; 64x64x5
- Anatomical volume: Axial SPGR; FOV=200 mm2; slice thickness=2mm; 256x256x40
- (a) Full View Stimulation: Full View of Screen: [Full, Dot] 5 cycles; 20 images/cycle
- (b) Top/Bottom Half View Stimulation: Half View of Screen: [Bot, Top] 5 cycles
- (c) Left/Right Half View Stimulation: Half View of Screen: [Left, Right] 5 cycles
Figure 2. (44K color, 712x489 gif)
The registrations were performed using our "MIAMI Fuse" (Mutual Information
for Automatic Multimodality Image Fusion) software as described fully in
Meyer, et al..
Figure 2. (44K color, 712x489 gif)
Figure 1. (13K color, 312x505 gif)